Anthonie Eduard du Toit, mathematician, was the son of Stephanus Georg du Toit and his wife Anna Aletta, born Smith. He passed the matriculation examination of the University of the Cape of Good Hope (an examining body only) in 1902. Continuing his studies at Victoria College, Stellenbosch (later the University of Stellenbosch), he was awarded the Bachelor of Arts (BA) degree with honours in mathematics by the University of the Cape of Good Hope in February 1906. That same year he was appointed assistant to Professor Lawrence Crawford* in the Department of Mathematics of the South African College, Cape Town (later the University of Cape Town). He also continued his studies there and in 1907 obtained the degree Master of Arts (MA) in mathematics from the university. At the end of 1907 he resigned his post and spent about two years in Paris, France.
Upon his return to South Africa in 1910 du Toit assisted Professor J.T. Morrison* in teaching applied mathematics at Victoria College. Around 1913 he was appointed professor of mathematics at the Transvaal University College, Pretoria. When the college became the University of Pretoria in 1930 he was appointed as its first principal.
Du Toit became a member of the South African Association for the Advancement of Science in 1913. In 1928, and again in 1938, he was appointed a member of the Statistical Council. The council was established in 1917 and made important recommendations about the collection and publication of population statistics. Du Toit was married to Anna Johanna Frederika Human, who survived him.