K.C.A. Schultz studied at the University College of the Orange Free State and was awarded the degree Bachelor of Science (BSc) by the University of South Africa in 1921. He then qualified as a veterinarian at the Veterinary Faculty of the University of Pretoria at Onderstepoort in 1925. The next year he became a member of the South African Veterinary Medical Association. In 1931 he was awarded the degree Dr Med Vet at the University of Leipzig, Germany, for his thesis Ein Beitrag zur Kenntnis der Pyometra des Rindes. Following service as a government veterinary officer at Otjiwarango (Namibia, 1926-1930), Kimberley (1932-1935) and Cape Town he joined the staff at Onderstepoort Veterinary Research Institute in the Department of Pathology. He also lectured in pathology at the Veterinary Faculty and was eventually promoted to professor and head of the department. His main interest was pathological conditions associated with mineral deficiencies.
While stationed at Kimberley Schultz was involved in a dramatic incident, having his lower jaw shattered by a shot from a farmer whose dourine infected horse he had to destroy.