George P. Yule (sometimes George Pratt-Yule) qualified as Bachelor of Medicine (MB) and Master in Surgery in 1894, then completed a Bachelor of Science (BSc) degree in Public Health (1896), and graduated as Doctor of Medicine (MD) at the University of Edinburgh in 1899. He became a member of the Royal College of Physicians of Edinburgh in 1900, and was elected a Fellow in 1904.
Yule came to South Africa in or before 1900 and in November that year entered the civil service of the Orange River Colony, created shortly after the British occupied the former Orange Free State during the Anglo-Boer War (1899-1902). In June 1901 he was appointed medical officer of health and registrar of births and deaths of the Orange River Colony. He was licensed to practice medicine in the colony in October 1902. Shortly after his appointment he wrote medical reports on the fulfilment of the recommendations of the refugee camp commission (September 1901) and on the Kroonstad and Brandford refugee camps (November 1901), as well as Refugee camps - mortality statistics (Bloemfontein, 1902, 44p). He became a member of the Philosophical Society of the Orange River Colony in 1903, the year it was established in Bloemfontein, and served on its committee for 1906/7. Around that time he presented a paper before the society on "Patent and proprietary medicines". In 1908 he delivered a paper on "Water supply" at the South African Medical Congress.
Yule was appointed an extraordinary member of the Legislative Council of the Orange River Colony in 1907. Following the formation of the Union of South Africa in 1910 he was retrenched in 1911 and that same year resigned from the Medical and Pharmacy Council of the Orange Free State. He was still registered as a medical practitioner in the Orange Free State by 1916, though at this time he resided at Cupar, Fife, Scotland.