Dr. Edward Guy Dru-Drury (or Drury, Edward Guy Dru) was the son of Col. Edward Dru Drury and Clara Howard Dru. He received his medical education at St Bartholomew's Hospital and University College London, being awarded the degrees Bachelor of Medicine (MB) and Bachelor of Surgery (BS) in 1896 and qualifying as a member of the Royal College of Surgeons of England (MRCS) and a licentiate of the Royal College of Physicians of London (LRCP) the same year. In 1898 he was awarded the degree Doctor of Medicine (MD), also in London. That same year he married Joan A. Wilkinson, with whom he had five children. He came to South Africa in 1899 and settled in Grahamstown. During the Anglo-Boer War (1899-1902) he was a civil surgeon and acted as medical officer to the British troops at Grahamstown.
After the war he served as district surgeon of Albany (1908-1923), railway medical officer in Grahamstown, and visiting medical officer at Albany General Hospital. He was a member of the British Medical Association and a Fellow of the Royal Society of Medicine. He joined the South African Association for the Advancement of Science as a foundation member in 1902 and served as a member of council in 1907/8 and 1908/9. In 1904 he donated a collection of geological specimens from England to the Albany Museum, and from the next year served on the museum's management committee to 1908. He also served on the committees of the library and the Arts Association in Grahamstown. In 1906 he accompanied Prof. G.E. Cory* to Graaff-Reinet in search of Bushman skulls and skeletons. During the same year he published an article on medical trade-unionism in the South African Medical Record. Also in 1906 he delivered a comprehensive lecture, "A chronicle of St John's lodge no. 828, E.C., Grahamstown, Cape Colony, from November 1860 to December 1906", which was published in London with a paper by O.H. Bate under the title "Some notes on South African masonic history". A second part of this chronicle was published in Grahamstown in 1910. He was awarded the Diploma in Public Health at Durham in 1908. By 1917 he had become a member of the Royal Society of South Africa.
During World War I (1914-1918) Dru-Drury was a captain in the South Africam Medical Corps and served in German South West Africa (now Namibia). After the war he resumed his professional activities in Grahamstown. He was chairman of the Grahamstown Mental Hospital Board, medical officer at Settler's Hospital in Grahamstown, and a member of the South African committee of the British Medical Association. Around 1920 he published several lectures and papers on a variety of topics: "Choosing a wife", a lecture delivered and published in Grahamstown in 1919; "Life below stairs", and "Psycho-analysis", both lectures to the Philosophical Circle of Rhodes University College in 1920; "A nervous breakdown", a paper before the Albany branch of the Trained Nurses' Association and published in East London; "Toxic idiopathies", published in the South African Medical Record (1920); "An extreme case of microcephaly", in Transactions of the Royal Society of South Africa (1919-1920, Vol. 8, pp. 149-153); "Malformation of the face, ear, eye and hand", in Transactions of the Royal Society of Medicine (1921); and "Stock-taking", presidential address to the Eastern Province branch of the British Medical Association and published in Cape Town (1921). During the nineteen-twenties he was a lecturer in anatomy at Rhodes University College; by 1930 he lectured there in anatomy and physiology, and the next year in physiology and hygiene.
Several photographs of scenes in the Eastern Cape taken by Dru-Drury during 1900-1926 are housed in the Cory Library, Grahamstown. The library also holds various papers relating to the municipality of Grahamstown, which he donated in 1902.